Great Royal Wife of Amenhotep III and the most prominent Egyptian queen of the 18th Dynasty; daughter of the non-royal Yuya and Tjuyu. Mother of Akhenaten and of Sitamun (whom Amenhotep III later took as Great Royal Wife). Her unprecedented public prominence — named beside the king on monuments and scarabs, a Nubian temple at Sedeinga where she was worshipped as a form of Hathor, and direct diplomatic correspondence in the Amarna Letters — set the stage for the elevated royal women of the Amarna period. Mortal-tier by descent (non-royal parents); the Sedeinga deification is a cultic honor recorded in the notes, not in the divinity fraction.